Single Cell Genomics - Lung Cell Atlas

Dr. Herbert Schiller (Helmholtz Zentrum München) and Prof. Christos Samakovlis (CPI, JLU Giessen and SciLifeLab Stockholm) have been appointed Adjunct Faculty of the Institute for Lung Health, where they oversee the area of single cell genomics. Single cell genomics (SCG) is currently transforming every aspect of the life sciences by providing deep insights into previously hidden diversity of cell subtypes and functionally distinct cell states. Several large international consortia such as the LifeTime Initiative and the Human Cell Atlas (HCA) have been formed in recent years to create reference maps of the cellular circuits forming human tissues in health and disease. Schiller and Samakovlis actively participate in these initiatives and develop experimental and analytical strategies to study lung disease using single cell analysis.

Dr. Herbert Schiller is deputy director of the Institute of Lung Biology and Disease at Helmholtz Zentrum München and a member of the German Center for Lung Research (DZL, CPC-M). He studied Genetics at the University of Vienna and obtained a PhD in Molecular Immunology at Medical University of Vienna, followed by postdoctoral work at the Max Planck Institute of Biochemistry in the laboratories of Reinhard Fässler and Matthias Mann. Herbert Schiller currently heads the research program `Cell Circuits in Systems Medicine of Lung Disease´ at the Helmholtz Zentrum München. The main aim of this research program is to understand how cells are wired together into circuits and thereby influence each other in lung health and disease. Genes interact in functional gene programs that ultimately constitute health or disease. Gene programs act on the level of individual cells but importantly also at tissue level across multiple cell types. Functionally connected multicellular circuits react as a coordinated unit in responses to environmental challenges and infections. The Schiller lab studies cellular and molecular perturbations in patient and mouse tissues, as well as organotypic ex vivo models at single cell resolution. This enables them to reconstruct regulatory cellular circuits and identify fundamental cellular and molecular mechanisms of lung disease and regeneration, as well as associated clinically relevant biomarkers.

Herbert Schiller - Google Scholar: https://scholar.google.com/citations?hl=en&user=XZt2fpYAAAAJ

Herbert Schiller - Pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=schiller+hb&sort=date

Contact

Dr. Herbert Schiller
Deputy Director
Institute of Lung Biology and Disease

Head of research program
Cell Circuits in Systems Medicine of Lung Disease

Helmholtz Zentrum München, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)

Max-Lebsche-Platz 31 (Room C2.17)
81377 München
Email: herbert.schiller@helmholtz-muenchen.de
Phone: +49 89 3187-1194

Twitter: @SchillerLab

Professor Christos Samakovlis is scientific director at SciLifeLab in Stockholm and member at the Cardiopulmonary Institute (CPI) in Giessen and the DZL. His work focuses on Drosophila airway and mammalian lung development aiming to understand developmental mechanisms that become dysregulated during chronic lung disease. He studied Biology at the Aristotle University in Thessaloniki, Greece. He received his Ph.D degree at Stockholm University, where he contributed to the foundations of the research field of innate immunity in Drosophila and vertebrates. During his postdoctoral work, at Stanford University he initiated the genetic dissection of cellular processes in respiratory organ development in flies. Ongoing work in the Samakovlis laboratory develops and utilizes high-resolution, single cell analysis technologies aiming to understand the developmental trajectories leading to a healthy mature lung and to discover how these programs become misdirected to cause terminal lung diseases.

Christos Samakovlis publications: https://pubmed.ncbi.nlm.nih.gov/?term=samakovlis+c&sort=date

Christos Samakovlis Google scholar: https://scholar.google.com/citations?hl=en&user=xYqJw8wAAAAJ