The lungs are highly susceptible to chronic disease in advanced age, likely due to the uniquely compromised repair function of alveolar type II (AT2) cells, facultative progenitor cells that maintain the gas exchange surface. Using aging mouse models, single-cell sequencing, and ex vivo organoid assays, we found that homeostatic aged AT2 cells exhibited an Interferon
- Jensen, J.
- Guo, K.
- Gote-Schniering, J.
- Mistry, M.
- Orinska, Z.
- Wang, J. Q.
- Melo-Narvaez, M. C.
- Boosarpu, G.
- Chahin, A.
- Paschini, M.
- Seymour, M.
- Pessina, P.
- Dang, S. M.
- Hu, Q.
- Ho Sui, S.
- Königshoff, M.
- Lehmann, M.
- Meiners, S.
- Kim, C. F.
