Stimuli-Specific Senescence of Primary Human Lung Fibroblasts Modulates Alveolar Stem Cell Function

Aging is the main risk factor for chronic lung diseases (CLDs) including idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Accordingly, hallmarks of aging like cellular senescence are increased in these patients in different lung cell types including fibroblasts. However, little is known about the different triggers that induce a senescence phenotype in different disease backgrounds and its role in CLD pathogenesis. Therefore, we characterized senescence in primary human lung fibroblasts (phLF) from control, IPF, or COPD patients at baseline and after exposure to disease-relevant insults (H(2)O(2), bleomycin, TGF-

  • Melo-Narváez, M. C.
  • Bramey, N.
  • See, F.
  • Heinzelmann, K.
  • Ballester, B.
  • Steinchen, C.
  • Jain, E.
  • Federl, K.
  • Hu, Q.
  • Dhakad, D.
  • Behr, J.
  • Eickelberg, O.
  • Yildirim, AÖ
  • Königshoff, M.
  • Lehmann, M.

Keywords

  • Humans
  • *Cellular Senescence/drug effects
  • *Fibroblasts/metabolism/drug effects
  • *Idiopathic Pulmonary Fibrosis/pathology/metabolism
  • *Lung/cytology/pathology
  • *Bleomycin/pharmacology
  • *Stem Cells/metabolism/drug effects/cytology
  • *Hydrogen Peroxide/pharmacology
  • Pulmonary Disease, Chronic Obstructive/pathology/metabolism
  • Transforming Growth Factor beta1/pharmacology/metabolism
  • Alveolar Epithelial Cells/metabolism/drug effects
  • Cells, Cultured
  • aging
  • cellular senescence
  • chronic lung diseases
  • fibroblasts
Publication details
DOI: 10.3390/cells13131129
Journal: Cells
Number: 13
Work Type: Original
Access number: 38994981
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