Background: Precision oncology treatments are being applied more commonly in breast and gynecological oncology through the implementation of Molecular Tumor Boards (MTBs), but real-world clinical outcome data remain limited. Methods: A retrospective analysis was conducted in patients with breast cancer (BC) and gynecological malignancies referred to our center's MTB from 2018 to 2023. The analysis covered patient characteristics, next-generation sequencing (NGS) results, MTB recommendations, therapy received, and clinical outcomes. Results: Sixty-three patients (77.8%) had metastatic disease, and forty-four patients (54.3%) had previously undergone three or more lines of systemic treatment. Personalized treatment recommendations were provided to 50 patients (63.3%), while 29 (36.7%) had no actionable target. Ultimately, 23 patients (29.1%) underwent molecular-matched treatment (MMT). Commonly altered genes in patients with pan-gyn tumors (BC and gynecological malignancies) included TP53 (n = 42/81, 51.9%), PIK3CA (n = 18/81, 22.2%), BRCA1/2 (n = 10/81, 12.3%), and ARID1A (n = 9/81, 11.1%). Patients treated with MMT showed significantly prolonged progression-free survival (median PFS 5.5 vs. 3.5 months, p = 0.0014). Of all patients who underwent molecular profiling, 13.6% experienced a major clinical benefit (PFSr
- Gremke, N.
- Rodepeter, F. R.
- Teply-Szymanski, J.
- Griewing, S.
- Boekhoff, J.
- Stroh, A.
- Tarawneh, T. S.
- Riera-Knorrenschild, J.
- Balser, C.
- Hattesohl, A.
- Middeke, M.
- Ross, P.
- Litmeyer, A. S.
- Romey, M.
- Stiewe, T.
- Wündisch, T.
- Neubauer, A.
- Denkert, C.
- Wagner, U.
- Mack, E. K. M.
Keywords
- breast cancer
- gynecological tumors
- molecular tumor board
- next-generation sequencing
- precision oncology
