Haptoglobin buffers lipopolysaccharides to delay activation of NF

It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show here that haptoglobin, a major serum protein with elusive immunoregulatory properties, binds and buffers bacterial lipopolysaccharides to attenuate activation of NF

  • Zein, L.
  • Grossmann, J.
  • Swoboda, H.
  • Borgel, C.
  • Wilke, B.
  • Awe, S.
  • Nist, A.
  • Stiewe, T.
  • Stehling, O.
  • Freibert, S. A.
  • Adhikary, T.
  • Chung, H. R.

Keywords

  • *Haptoglobins/metabolism
  • *Lipopolysaccharides
  • *NF-kappa B/metabolism
  • Humans
  • Macrophages/immunology/metabolism
  • Animals
  • Toll-Like Receptor 4/metabolism
  • Mice
  • Protein Binding
  • Signal Transduction
  • RAW 264.7 Cells
  • Lps
  • LPS buffering
  • NFkB
  • Tlr4
  • haptoglobin
  • lipopolysaccharide
Publication details
DOI: 10.3389/fimmu.2024.1401527
Journal: Front Immunol
Pages: 1401527
Work Type: Original
Access number: 39416789
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