It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show here that haptoglobin, a major serum protein with elusive immunoregulatory properties, binds and buffers bacterial lipopolysaccharides to attenuate activation of NF
- Zein, L.
- Grossmann, J.
- Swoboda, H.
- Borgel, C.
- Wilke, B.
- Awe, S.
- Nist, A.
- Stiewe, T.
- Stehling, O.
- Freibert, S. A.
- Adhikary, T.
- Chung, H. R.
Keywords
- *Haptoglobins/metabolism
- *Lipopolysaccharides
- *NF-kappa B/metabolism
- Humans
- Macrophages/immunology/metabolism
- Animals
- Toll-Like Receptor 4/metabolism
- Mice
- Protein Binding
- Signal Transduction
- RAW 264.7 Cells
- Lps
- LPS buffering
- NFkB
- Tlr4
- haptoglobin
- lipopolysaccharide