RATIONALE: Echocardiographic indicators of pulmonary hypertension have been reported to predict decreased survival in lung cancer. OBJECTIVE: We tested the hypothesis that this may be associated with impaired right ventricular (RV)-systolic pulmonary arterial pressure (sPAP) coupling. METHODS: This prospective observational study included 220 outpatients with non-small cell lung cancer (NSCLC) examined by Doppler, strain, and 3-dimensional echocardiography before starting therapy. Of the included patients, 41% were female and the median age was 68 years [61, 74]. Prediction of one-year overall survival was assessed by univariable analysis followed by multivariate Cox regression, receiver operating characteristic (ROC) curves and Kaplan-Meier analyses. RESULTS: Median sPAP was within the limits of normal (31 mmHg [26, 36]); 30% of the patients had sPAP
- Rako, Z. A.
- Cekay, M.
- Yogeswaran, A.
- Yildiz, S.
- Arndt, P. F.
- Kremer, N.
- Schaefer, S.
- Janetzko, P.
- Brito da Rocha, B.
- Mummert, C. M.
- Franken, J. K.
- Soethe, H.
- Werner, H. F.
- Dumitrascu, R.
- Grimminger, F.
- Ghofrani, H. A.
- Pullamsetti, S. S.
- Seeger, W.
- Naeije, R.
- Savai, R.
- Eul, B.
- Tello, K.
