Mitochondrial reactive oxygen species (mtROS) have been implicated in the development of chronic hypoxia-induced pulmonary hypertension (PH), potentially through hypoxia-inducible factor-1
- Zeidan, E. M.
- Nagarajan, S. A.
- Sydykov, A.
- Bier, J.
- Brosien, M.
- Taye, A.
- Pak, O.
- Ghofrani, H. A.
- Schermuly, R. T.
- Seeger, W.
- Weissmann, N.
- Sommer, N.
- Nardiello, C.
Keywords
- Animals
- Male
- *Organophosphorus Compounds/pharmacology/therapeutic use
- Mice
- *Hypertension, Pulmonary/etiology/metabolism/drug therapy
- *Hypoxia/complications/metabolism
- Cell Proliferation/drug effects
- Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
- Humans
- Myocytes, Smooth Muscle/drug effects/metabolism
- *Antioxidants/pharmacology/therapeutic use
- Mitochondria/metabolism/drug effects
- Pulmonary Artery/drug effects/metabolism
- Mice, Inbred C57BL
- Reactive Oxygen Species/metabolism
- Piperidines
- Hif‐1α
- chronic hypoxia
- mitoTEMPO
- pulmonary hypertension
