Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner

BACKGROUND: Bronchopulmonary dysplasia (BPD) is one common and severe complication of preterm births. Prenatal infection/inflammation is the major cause driving preterm deliveries, but its contribution to the early-life lung development remains unclear. METHODS: Pregnant C57BL/6J mice were randomized at 15.5 or 18.5 days post coitum (dpc) to receive intraperitoneal injection of sterile saline, lipopolysaccharide (LPS) 50

• Dong, Y.
• Hadzic, S.
• Leidner, A.
• Marega, M.
• Procida-Kowalski, T.
• Bartkuhn, M.
• Rivetti, S.
• Ehrhardt, H.
• Bellusci, S.