Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) and breast cancer disproportionately affect women. BMPR2 (bone morphogenetic protein receptor type 2) mutations, the most common genetic cause of heritable PAH, also exert tumor-suppressive functions, but their role in linking these diseases remains unclear. METHODS: We combined bioinformatic, epidemiologic, and experimental approaches. Public cancer datasets were mined for BMPR2 alterations. In vivo, mammary tumor development and pulmonary hemodynamics were assessed in female Bmpr2(+/

• Toro, V.
• Mougin, M.
• Brossat, C.
• Jambon-Barbara, C.
• Hlavaty, A.
• Guay, C. A.
• El Kabbout, R.
• Bilodeau, C.
• Grobs, Y.
• Martineau, S.
• Breuils-Bonnet, S.
• Abi-Sleimen, A.
• Ruffenach, G.
• Boucherat, O.
• Bisserier, M.
• Provencher, S.
• Bonnet, S.
• Montani, D.
• Khouri, C.
• Potus, F.