Deficiency of Smooth Muscle ADAR1 Exacerbates Vascular Remodeling and Pulmonary Hypertension

BACKGROUND: ADAR1 (adenosine deaminase acting on RNA 1) catalyzes the conversion of adenosine to inosine in double-stranded RNAs, which is critical to prevent autoinflammatory responses mediated by activation of the type I IFN (interferon) signaling. We define the role of ADAR1-dependent RNA editing in IFN

• Kim, Y.
• Maroli, G.
• Woodcock, C. C.
• Kim, H.
• Liu, Y.
• Klouda, T.
• Li, Y.
• Li, Q.
• Hao, Y.
• Schumacher, V.
• Turton, H. A.
• Thompson, A. A. R.
• Looso, M.
• Kuenne, C.
• Valasarajan, C.
• Ruppert, C.
• Avolio, T.
• Tang, Y.
• Tai, Y. Y.
• Kudryashova, T. V.
• Goncharova, E. A.
• Wu, J. C.
• Li, J. B.
• Bertero, T.
• Savai, R.
• Raby, B. A.
• Chan, S. Y.
• Pullamsetti, S. S.
• Yuan, K.