Influenza A virus (IAV) infection causes acute and long-term lung damage. Here, we used immunostaining, genetic, and pharmacological approaches to determine whether IAV-induced cellular senescence causes prolonged alterations in lungs. Mice infected with a sublethal dose of H1N1p2009 exhibited cellular senescence, as evidenced by increased pulmonary expression of p16, p21,
- Lipskaia, L.
- Delval, L.
- Sencio, V.
- Born, E.
- Heumel, S.
- Houssaini, A.
- Valentin, C.
- Raviola, S.
- Deruyter, L.
- Angulo, F. S.
- Gros, V.
- Marcos, E.
- Abid, S.
- Goekyildirim, M.
- Contreras, V.
- Flaman, J. M.
- Le Grand, R.
- Le Goffic, R.
- Bernard, D.
- Adnot, S.
- Trottein, F.
Keywords
- acute response
- cellular senescence
- chronic damage
- epithelial damage
- fibrosis
- genetic approach
- influenza
- senolysis
