The SIRT7-nucleolus connection in cancer: ARF enters the fray

The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ARF) within the nucleolus, aiding cancer progression. We propose that targeting nucleolar SIRT7 offers promise for new anti-cancer therapies.

  • Tarighi, S.
  • Kumari, P.
  • Vaquero, A.
  • Braun, T.
  • Ianni, A.

Keywords

  • Sirt7
  • Sirtuin 7
  • cancer
  • nucleolus
Publication details
DOI: 10.1080/23723556.2024.2381287
Journal: Mol Cell Oncol
Pages: 2381287
Number: 1
Work Type: Original
Access number: 39036727
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