Defective DNA repair and metabolic rewiring are highly intertwined in promoting the development and progression of cancer. However, the molecular players at their interface remain poorly understood. Here we show that an RNF20-HIF1
- Liu, H.
- Tang, Y.
- Singh, A.
- Vong, J.
- Cordero, J.
- Mathes, A.
- Gao, R.
- Jia, Y.
- Garvalov, B. K.
- Acker, T.
- Poschet, G.
- Hell, R.
- Schneider, M. A.
- Heineke, J.
- Wieland, T.
- Barreto, G.
- Cerwenka, A.
- Potente, M.
- Bibli, S. I.
- Savai, R.
- Dobreva, G.
Keywords
- *Hypoxia-Inducible Factor 1, alpha Subunit/metabolism/genetics
- Animals
- *Ubiquitin-Protein Ligases/metabolism/genetics
- *Lung Neoplasms/metabolism/genetics/pathology
- Humans
- Mice
- *DNA Damage
- Histones/metabolism
- Epithelial-Mesenchymal Transition/genetics
- Cell Line, Tumor
- Gene Expression Regulation, Neoplastic
- Mice, Knockout
- Tumor Suppressor Protein p53/metabolism/genetics
- DNA Repair
- Von Hippel-Lindau Tumor Suppressor Protein/metabolism
- Ubiquitination
- Female
- Male
- RNA Polymerase II/metabolism
