Nebulization of RNA-Loaded Micelle-Embedded Polyplexes as a Potential Treatment of Idiopathic Pulmonary Fibrosis

Biodegradable poly(

  • Müller, J. T.
  • Kromer, A. P. E.
  • Ezaddoustdar, A.
  • Alexopoulos, I.
  • Steinegger, K. M.
  • Porras-Gonzalez, D. L.
  • Berninghausen, O.
  • Beckmann, R.
  • Braubach, P.
  • Burgstaller, G.
  • Wygrecka, M.
  • Merkel, O. M.

Keywords

  • Humans
  • *Idiopathic Pulmonary Fibrosis/drug therapy/therapy/pathology
  • *Micelles
  • *RNA, Small Interfering/chemistry/metabolism/pharmacology
  • *Nebulizers and Vaporizers
  • Polymers/chemistry
  • Matrix Metalloproteinase 7/metabolism/genetics
  • Nanoparticles/chemistry
  • Collagen Type I/chemistry/genetics/metabolism
  • Pbae
  • idiopathic pulmonary fibrosis
  • micelle-embedded polyplex
  • micelleplex
  • polyplex
  • siRNA
  • vibrating-mesh nebulizer
Publication details
DOI: 10.1021/acsami.4c21657
Journal: ACS Appl Mater Interfaces
Pages: 11861-11872
Number: 8
Work Type: Original
Access number: 39938880
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