Mitochondrien als universelle Sensoren der akuten Hypoxie?

Adaptation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation. Acute oxygen sensing thus is a fundamental pre-requisite for aerobic life. Recent studies unravelled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that regulates the release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses.

  • Nolte, A.
  • Pak, O.
  • Sommer, N.
Publication details
DOI: 10.1007/s12268-022-1742-5
Journal: Biospektrum (Heidelb)
Pages: 132-134
Number: 2
Work Type: Review
Access number: 35369109
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