This study highlights the previously unknown association of mosaic loss of the Y chromosome to impaired gas exchange and cardiac dysfunction, implicating mosaicism in immune-mediated, multi-organ decline and revealing a mechanistic basis for sex-biased vulnerability in COPD.
- Valasarajan, C.
- Rasper, T.
- Wilhelm, J.
- Dhakad, D.
- Kuhnert, S.
- Seeger, W.
- Dimmeler, S.
- Bals, R.
- Savai, R.
- Yildirim, AÖ
- Zeiher, A.
- Pullamsetti, S. S.
Keywords
- Humans
- *Pulmonary Disease, Chronic Obstructive/genetics/physiopathology
- Male
- *Chromosomes, Human, Y/genetics
- Female
- *Lung/physiopathology
- *Heart Diseases/genetics
- Aged
- Middle Aged
