S\u00e9bastien Bonnet, PhD, FAHA, is a Full Professor of Medicine at Universit\u00e9 Laval and Director of the Pulmonary Hypertension and Vascular Biology Research Group at the Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (CRIUCPQ). He holds a Distinguished Research Chair from the Fonds de recherche du Qu\u00e9bec \u2013 Sant\u00e9 (FRQS) and is internationally recognized for his pioneering work in pulmonary vascular biology, with a particular focus on pulmonary arterial hypertension (PAH), right ventricular failure (RVF), and coronary artery disease (CAD).<\/p>\n
Dr. Bonnet\u2019s translational research program is built on a unique and dynamic collaboration between fundamental and clinical scientists. With a strong emphasis on epigenetics, cellular metabolism, DNA damage, and biomarker discovery, his team has been at the forefront of identifying critical mechanisms underlying vascular remodeling and RV dysfunction. These discoveries are driving the development of targeted therapies and diagnostic tools aimed at transforming patient care.<\/p>\n
In addition to his role in Qu\u00e9bec, Dr. Bonnet is now also affiliated part-time with the Institute for Lung Health (ILH) of Justus Liebig University (JLU) in Giessen, Germany. There, he collaborates closely with Professors Soni Pullamsetti and Rajkumar Savai on cutting-edge research into pulmonary vascular diseases and lung cancer, enhancing global efforts in translational lung research.<\/p>\n
Dr. Bonnet earned his PhD in Health and Biology from Universit\u00e9 de Bordeaux 2, France, where he studied potassium channels and intracellular calcium signaling in PAH. He completed his postdoctoral training and early academic career at the University of Alberta before joining Universit\u00e9 Laval in 2008.<\/p>\n
A Fellow of the American Heart Association (FAHA), he has held prestigious Canadian Research Chairs in both Vascular Biology and Translational Pulmonary Vascular Disease. He has taken on major leadership roles including Chair of the 3CPR Council of the AHA and board member of the Pulmonary Vascular Research Institute (PVRI). He also serves on the editorial boards of numerous high-impact journals, including Circulation<\/em>, Circulation Research<\/em>, and the American Journal of Physiology<\/em>.<\/p>\n Dr. Bonnet\u2019s group has made major contributions to the field, including the development of the first internationally endorsed preclinical\/translational research guidelines for PAH, endorsed by the World Symposium on Pulmonary Hypertension in 2018. His lab was among the first to propose the \u201ccancer theory of PAH,\u201d highlighting parallels between PAH and cancer biology, such as resistance to apoptosis, metabolic reprogramming, and abnormal cell proliferation. These insights have led to the discovery of novel biomarkers and therapeutic targets, including microRNAs, long non-coding RNAs (lncRNAs), BET proteins, and DNA damage response pathways.<\/p>\n Currently, his team is actively involved in translating these findings into clinical practice through multicenter trials (e.g., NCT03782818, NCT03655704), as well as contributions to studies on DHEA and trimetazidine. Beyond research, Dr. Bonnet is deeply committed to mentorship and has trained over 60 students and fellows, fostering a collaborative and inclusive environment that promotes innovation and excellence.<\/p>\n Driven by the urgent need for more effective treatments, his translational approach aims to deliver personalized therapies that improve both outcomes and quality of life for patients living with cardiopulmonary diseases.<\/p>\n Interests: <\/p>\n Dr. S\u00e9bastien Bonnet PhD; F.A.H.A<\/p>\n Professeur en m\u00e9decine \/ Full Professor in medicine<\/p>\n Distinguished Research Scholars FRQS chair Centre de recherche de IUCPQ 2725\u00a0Chemin\u00a0Sainte-Foy Phone: +1 418 656 8711 ext 5427 (lab) 3728 (office) <\/p>\n Other publications: https:\/\/pubmed-ncbi-nlm-nih-gov.acces.bibl.ulaval.ca\/?term=Sebastien+Bonnet&sort=date<\/a><\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Prof. Dr. S\u00e9bastien Bonnet S\u00e9bastien Bonnet, PhD, FAHA, is a Full Professor of Medicine at Universit\u00e9 Laval and Director of the Pulmonary Hypertension and Vascular Biology Research Group at the Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec (CRIUCPQ). He holds a Distinguished Research Chair from the Fonds de recherche […]<\/p>\n","protected":false},"author":20,"featured_media":19506,"parent":19246,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"class_list":["post-23869","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/23869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/comments?post=23869"}],"version-history":[{"count":10,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/23869\/revisions"}],"predecessor-version":[{"id":23880,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/23869\/revisions\/23880"}],"up":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/19246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/media\/19506"}],"wp:attachment":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/media?parent=23869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/strong>Pulmonary arterial hypertension (PAH); Right ventricular failure; coronary disease.<\/p>\n<\/h4>\n
Contact<\/h4>\n
\nDirecteur du comit\u00e9 3CPR of American Heart Association \/ Chair of the American Heart Association 3CPR council
\nGroupe de recherche en hypertension pulmonaire \/ Pulmonary hypertension research group<\/p>\n
\nLocal A2134
\nG1V 4G5 Qu\u00e9bec, (Qu\u00e9bec) Canada<\/p>\n
\nEmail: Sebastien.Bonnet@criucpq.ulaval.ca<\/a>
\nWeb: https:\/\/phrg.ca\/<\/a><\/p>\nTen most important publications<\/h4>\n
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Here you can find all ILH-publications<\/a><\/h4>\n