{"id":19194,"date":"2020-11-23T13:05:29","date_gmt":"2020-11-23T12:05:29","guid":{"rendered":"https:\/\/ilh-giessen.de\/?page_id=19194"},"modified":"2024-09-05T13:58:38","modified_gmt":"2024-09-05T11:58:38","slug":"our-mission","status":"publish","type":"page","link":"https:\/\/ilh-giessen.de\/en\/our-mission\/","title":{"rendered":"Our Mission"},"content":{"rendered":"<p style=\"text-align: center;\"><em>The Institute for Lung Health uncovers the molecular and cellular mechanisms underlying maintenance of lung health and their failure in lung disease, and develops etiology-based preventive and regenerative therapies.<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>The ILH sets up interdisciplinary teams that strive to achieve the following goals using a translational bedside-to-bench and bench-to-bedside approach:<\/p>\n<ul>\n<li>To identify the key cellular players, signaling networks, and molecular switches and the underlying genetic\/epigenetic control mechanisms ensuring the maintenance of lung architecture and its resilience to environmental challenge under healthy conditions.<\/li>\n<li>To identify the changes in epigenetic control, signaling mechanisms and cellular phenotypes driving pathological remodeling processes with loss of proper lung parenchymal structure and function in acute and chronic pulmonary diseases.<\/li>\n<li>To harness such knowledge for the development of novel preventive and therapeutic strategies for lung repair and regeneration, employing a broad armamentarium of preclinical approaches (cell culture, animal models, human organoid models, computational modeling; use of compound libraries, high-throughput drug discovery platforms).<\/li>\n<li>To transfer such novel treatment concepts into the clinical arena (analysis of biobank material and cohorts; development and clinical validation of prognostic and predictive novel biomarkers; phase I and II clinical studies in new preventive\/therapeutic strategies employing existent clinical study networks; alliances with industrial partners for further promotion of novel drug development).<\/li>\n<\/ul>\n<p>Thus, advanced biomedical and biotechnological expertise will be partnered with preclinical and clinical research competence in lung disease to achieve transformative breakthroughs in this field.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Institute for Lung Health uncovers the molecular and cellular mechanisms underlying maintenance of lung health and their failure in lung disease, and develops etiology-based preventive and regenerative therapies. &nbsp; The ILH sets up interdisciplinary teams that strive to achieve the following goals using a translational bedside-to-bench and bench-to-bedside approach: To identify the key cellular [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":19502,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_analysis_target_kw":"","footnotes":""},"class_list":["post-19194","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/19194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/comments?post=19194"}],"version-history":[{"count":7,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/19194\/revisions"}],"predecessor-version":[{"id":22755,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/pages\/19194\/revisions\/22755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/media\/19502"}],"wp:attachment":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/media?parent=19194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}