{"id":22951,"date":"2024-11-14T13:44:48","date_gmt":"2024-11-14T12:44:48","guid":{"rendered":"https:\/\/ilh-giessen.de\/?post_type=highlighted_pub&#038;p=22951"},"modified":"2024-11-14T13:44:48","modified_gmt":"2024-11-14T12:44:48","slug":"october-2024","status":"publish","type":"highlighted_pub","link":"https:\/\/ilh-giessen.de\/en\/highlighted_pub\/october-2024\/","title":{"rendered":"October 2024"},"content":{"rendered":"<div id=\"text_block-65-544\" class=\"ct-text-block news-text\">\n<div id=\"text_block-65-544\" class=\"ct-text-block news-text\">\n<div id=\"text_block-69-313-1\" class=\"ct-text-block news-text\" data-id=\"text_block-69-313\">\n<p><strong>Lingampally and colleagues<\/strong> from the <strong>Institute for Lung Health<\/strong> identified a subcluster of activated myofibroblasts (aMYFs) that may have significant implications the future management of idiopathic pulmonary fibrosis (IPF).<\/p>\n<p>IPF is a progressive, irreversible lung disease characterized by excessive extracellular matrix deposition. From a cell biology perspective, aMYFs are thought to secrete extracellular matrix and drive structural remodeling.<\/p>\n<p>Using genetic lineage tracing and single-cell transcriptomics, Lingampally and colleagues investigated the origin of aMYFs and their differentiation trajectories during the process of fibrosis formation and resolution.<\/p>\n<p>For the first time, the researchers demonstrate the heterogeneity of aMYFs, identifying subclusters with differing roles - some exhibit distinct pro-alveologenic, while others pro-fibrotic properties. Lipofibroblasts play a major role in emergence and fate of aMYFs during fibrogenesis and resolution, respectively.<\/p>\n<p>This work provides new insights into the cellular dynamics of IPF and may inform future therapeutic strategies to treat or reverse fibrosis.<\/p>\n<p><strong>Find the full article here:<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39401861\/\">Evidence for a lipofibroblast-to- Cthrc1 + myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice - PubMed<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>Source: October <a href=\"https:\/\/cpi-online.de\/researchofthemonth\/october-2024\/\" target=\"_blank\" rel=\"noopener\">2024 (cpi-online.de)<\/a><\/p>\n","protected":false},"featured_media":22952,"template":"","class_list":["post-22951","highlighted_pub","type-highlighted_pub","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/highlighted_pub\/22951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/highlighted_pub"}],"about":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/types\/highlighted_pub"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/media\/22952"}],"wp:attachment":[{"href":"https:\/\/ilh-giessen.de\/en\/wp-json\/wp\/v2\/media?parent=22951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}